|Description||GPR161 rabbit polyclonal|
|Protein full name||G-protein coupled receptor 161|
|Synonyms||Gpr161, Gm208, RE2, G protein coupled receptor RE2|
|Immunogen||KLH conjugated Synthetic peptide
corresponding to Mouse GPR161
|Predicted MW.||60 kDa|
|Observed MW.||65 kDa|
|WB||Mouse, Rat||1: 500-1: 1000||heart, brain|
GPR161 (also known as RE2) is an orphan G protein-coupled receptor and plays important roles in the Hh pathway. In the absence of Hh signals, GPR161 localizes to primary cilia and keeps the downstream GLI transcription factors in their repressor forms . Ciliary localization of GPR161 requires TULP3 and the IFT-A complex. In presence of SHH, GPR161 is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling.
Western blot analysis of GPR161 (GB111421) at dilution of 1: 1000
|Storage||Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.|
|Storage Buffer||PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.|
NOTE: This product is intended for research only.